Hypertrophic cardiomyopathy and fibrosis: correlation between late gadolinium enhancement on CMR and speckle tracking imaging using Ultrasound
نویسندگان
چکیده
Background Hypertrophic cardiomyopathy (HCM) is the most frequent genetic cardiovascular disorder and represents one of the most common cause of heart related sudden death in young adults. Myocardial fibrosis seems to be an independant predictor of adverse events including sudden death, ventricular arrhythmias and heart failure. While late gadolinium enhancement (LGE) on Cardiac Magnetic Resonance (CMR) is actually the gold-standard to detect fibrosis, new techniques are being evaluated such as 2D strain echocardiography.
منابع مشابه
Myocardial fibrosis delineation in late gadolinium enhancement images of Hypertrophic Cardiomyopathy patients using deep learning methods
Introduction: Accurate delineation of myocardial fibrosis in Late Gadolinium Enhancement on Cardiac Magnetic Resonance (LGE-CMR) has a crucial role in the assessment and risk stratification of HCM patients. As this is time-consuming and requires expertise, automation can be essential in accelerating this process. This study aims to use Unet-based deep learning methods to automate the mentioned ...
متن کاملExtent of late gadolinium enhancement in patients with hypertrophic cardiomyopathy in correlation with serum MMP9 as an indicator of myocardial fibrosis
Results Nine out of 50 patients with HCM (18 %) showed no fibrosis on LGE-CMR. In the remaining 41 patients, mean size of fibrosis was 13,3 ± 10,3% on LGE-CMR. In all patients, the mean MMP9 level was 54,4 ± 35,2 ng/ ml. Size of fibrosis on LGE-CMR strongly correlated with MMP9 levels (R2 = 0,557, Pearson’s r = 0,75, p < 0,01). In the 9 patients with no LGE, MMP9 was with 29,6 ± 14,2 ng/ml sign...
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Background CMR has become the leading modality to define the clinical impact of hypertrophic cardiomyopathy (HCM) providing complete coverage of both ventricles with high spatial resolution. Late gadolinium enhancement (LGE) accurately identifies regions of myocardial fibrosis. Via CMR, innumerable studies have established that LVH and LGE are the predominant phenotypic expressions of HCM. It i...
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Background Myocardial fibrosis is associated with abnormal cardiac remodeling and poor prognosis in patients with hypertrophic cardiomyopathy. Currently, new cardiac MRI (CMR) techniques such as T1-mapping and extracellular volume (ECV) measurement are available to quantify diffuse myocardial fibrosis. We analyzed the size of myocardial fibrosis using preand post-contrast T1, ECV and late gadol...
متن کاملNon-contrast T1rho CMR for hypertrophic cardiomyopathy
Background Hypertrophic cardiomyopathy (HCM) is a genetic disease characterized by heterogeneous clinical symptoms and able to be visualized by cardiac magnetic resonance (CMR). Late gadolinium enhancement (LGE) represents myocardial fibrosis. There is still a challenge for HCM patients with contrast agent contraindication. T1rho CMR has been reported to determine fibrosis in myocardial infarct...
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عنوان ژورنال:
دوره 17 شماره
صفحات -
تاریخ انتشار 2015